Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537670 | 1.00 | TBXAS1 (0.57) | TBXAS1HDAC8HDAC1PDE4BMAPT | |
| SCHEMBL8538471 | 0.84 | SMN1; SMN2 (0.50) | TBXAS1HDAC1ALDH1A1GAAHTT | |
| SCHEMBL8536355 | 0.82 | TBXAS1 (0.57) | TBXAS1MAPTNAMPT | |
| SCHEMBL8538811 | 0.82 | TBXAS1 (0.51) | TBXAS1MAPTHTTSMN1; SMN2NAMPT | |
| SCHEMBL8536541 | 0.82 | TBXAS1 (0.50) | TBXAS1ALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL4642330 | 0.81 | THRA (0.57) | TBXAS1 | |
| SCHEMBL8536914 | 0.81 | TBXAS1 (0.56) | TBXAS1NAMPT | |
| SCHEMBL5597244 | 0.80 | THRA (0.55) | TBXAS1 | |
| SCHEMBL8535819 | 0.80 | TBXAS1 (0.48) | TBXAS1ALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL8535356 | 0.80 | TBXAS1 (0.48) | TBXAS1ALDH1A1GAAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750532-A | TETRAHYDROPYRIMIDINE-2,4-DIONE DERIVATIVES, VIRICIDES, ANTIINFLAMMATORY AGENTS, PAF INHIBITORS | SCHERING CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |