Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9698890 | 0.92 | MPO (0.63) | HTR1AMPOSLC6A4ADRA2AADRA2B | |
| SCHEMBL8543491 | 0.90 | ADRA2A (0.67) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8544409 | 0.90 | ADRA2A (0.66) | MPOSLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL9698233 | 0.90 | ADRA2A (0.61) | HTR1AMPOSLC6A4ADRA2AADRA2B | |
| SCHEMBL8539206 | 0.90 | ADRA2A (0.70) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9266157 | 0.87 | ADRA2A (0.71) | HTR1AMPOSLC6A4ADRA2AADRA2B | |
| SCHEMBL8539583 | 0.86 | ADRA2A (0.68) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8543575 | 0.85 | ADRA2A (0.56) | HTR1ASLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL8542507 | 0.85 | ADRA2A (0.80) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8539816 | 0.84 | ADRA2A (0.77) | HTR1AADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496222-B1 | Indole derivatives | MERCK PATENT GMBH (DE) | 1998-09-09 | — | — | EP | disclosed |
| EP-0496222-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |