Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.68 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.68 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8542507 | 0.92 | ADRA2A (0.80) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8543491 | 0.92 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8541528 | 0.92 | ADRA2A (0.68) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8544409 | 0.92 | ADRA2A (0.66) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8539356 | 0.89 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8544902 | 0.88 | ADRA2A (0.64) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8539816 | 0.87 | ADRA2A (0.77) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8539458 | 0.86 | HTR1A (0.59) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8539206 | 0.86 | ADRA2A (0.70) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9265490 | 0.86 | ADRA2A (0.80) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496222-B1 | Indole derivatives | MERCK PATENT GMBH (DE) | 1998-09-09 | — | — | EP | disclosed |
| EP-0496222-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |