Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 5/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | ADK | P55263 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540664 | 0.78 | TAAR1 (0.48) | TAAR1ARMTORADKNISCH | |
| SCHEMBL5271255 | 0.74 | ROCK2 (0.43) | TAAR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8536464 | 0.71 | TAAR1 (0.45) | TAAR1MTORADKNISCHPIK3CD | |
| SCHEMBL9952337 | 0.70 | TAAR1 (0.44) | TAAR1MTORADKNISCHPTGES | |
| SCHEMBL2651232 | 0.70 | CSNK1A1 (0.49) | PDE4APDE4BPDE4CPDE4DMTOR | |
| SCHEMBL29360220 | 0.70 | CSNK1A1 (0.49) | TAAR1MTORADKNISCHTRPA1 | |
| SCHEMBL773131 | 0.70 | CSNK1A1 (0.49) | TAAR1MTORADKNISCHTRPA1 | |
| SCHEMBL7235096 | 0.70 | TAAR1 (0.49) | TAAR1MTORADKNISCHTRPA1 | |
| SCHEMBL20497275 | 0.69 | LRRK2 (0.46) | TAAR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4765948 | 0.69 | LRRK2 (0.44) | PDE4APDE4BPDE4CPDE4DMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |