Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.68 |
| ▸ | BCHE | P06276 | 4/20 | 0.68 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543795 | 0.90 | BCHE (0.64) | ACHEBCHE | |
| SCHEMBL8537924 | 0.88 | BCHE (0.60) | ACHEBCHE | |
| SCHEMBL8543195 | 0.88 | BCHE (0.61) | ACHEBCHENPC1RAB9A | |
| SCHEMBL8846198 | 0.85 | ACHE (0.61) | ACHEBCHEMAOAMAPTTHRB | |
| SCHEMBL9672311 | 0.84 | BCHE (0.49) | ACHEBCHE | |
| SCHEMBL8539327 | 0.84 | BCHE (0.49) | ACHEBCHEMAOAALDH1A1KDM4E | |
| SCHEMBL7616001 | 0.83 | BCHE (0.44) | ACHEBCHEPTGDR2HPGDS | |
| SCHEMBL2846516 | 0.81 | BCHE (1.00) | ACHEBCHEMAOAALDH1A1HPGDS | |
| SCHEMBL7620284 | 0.80 | BCHE (0.43) | ACHEBCHEMAOANPC1MAPT | |
| SCHEMBL8544660 | 0.80 | BCHE (0.43) | ACHEBCHEPTGDR2HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5102891-A | Useful for treating various memory dysfunctions such as alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-04-07 | — | — | US | claimed |
| EP-0468401-B1 | 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-09-16 | — | — | EP | disclosed |
| US-5102891-A | Useful for treating various memory dysfunctions such as alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-04-07 | — | — | US | disclosed |
| EP-0468401-A2 | 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-01-29 | — | — | EP | disclosed |