Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 8/20 | 0.37 |
| ▸ | CTSK | P43235 | 7/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8535555 | 0.73 | ATM (0.50) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL19126687 | 0.70 | KCNA5 (0.49) | ATMIDO1LMNA | |
| SCHEMBL6447422 | 0.69 | ATM (0.56) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL15095217 | 0.69 | ATM (0.46) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL23898232 | 0.68 | MMP13 (0.37) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL20830130 | 0.67 | PPARA (0.37) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL20830135 | 0.67 | CA1 (0.36) | CTSSCTSKCTSLCTSB | |
| SCHEMBL7839228 | 0.67 | ATM (0.41) | ATMMAPTALDH1A1SCN9A | |
| SCHEMBL17713927 | 0.67 | CTSS (0.50) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL15414493 | 0.67 | ATM (0.50) | ATMCTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |