Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 10/20 | 0.39 |
| ▸ | ATF1 | P18846 | 9/20 | 0.39 |
| ▸ | XPO1 | O14980 | 4/20 | 0.38 |
| ▸ | JUN | P05412 | 2/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.33 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8542943 | 0.86 | KDM4E (0.40) | KDM4ENFKB1ATF1XPO1JUN | |
| SCHEMBL8539891 | 0.77 | NFKB1 (0.55) | KDM4ENFKB1ATF1XPO1JUN | |
| SCHEMBL79014 | 0.77 | NFKB1 (0.60) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL3606702 | 0.77 | CTSS (0.32) | NFKB1JUNNFKB2RELA | |
| SCHEMBL3066551 | 0.76 | KDM4E (0.46) | KDM4ENFKB1ATF1XPO1JUN | |
| SCHEMBL14070976 | 0.76 | NFKB1 (0.41) | KDM4ENFKB1ATF1XPO1JUN | |
| SCHEMBL28280544 | 0.73 | KDM4E (0.41) | KDM4ENFKB1ATF1MAPT | |
| SCHEMBL3441123 | 0.73 | NFKB1 (0.40) | KDM4ENFKB1ATF1XPO1JUN | |
| SCHEMBL3060847 | 0.71 | NFKB1 (0.38) | KDM4ENFKB1ATF1XPO1JUN | |
| Water SCHEMBL4593114 | 0.66 | MAPT (0.56) | KDM4ENFKB1ATF1XPO1JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811428-A | ADMINISTERING FOR THE TREATMENT AND PREVENTION OF IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-22 | — | — | US | disclosed |
| EP-0850228-A1 | PYRIMIDINE CARBOXAMIDES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997009315-A1 | PYRIMIDINE CARBOXAMIDES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |