SCHEMBL8540440

SCHEMBL8540440

Sc1ccccc1-n1cnnn1

nearest known ligand 0.58

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.58
NPSR1 Q6W5P4 1/20 0.58
NOTUM Q6P988 5/20 0.53
KMT2A Q03164 3/20 0.45
KDM4E B2RXH2 1/20 0.45
NPC1 O15118 1/20 0.42
F2 P00734 1/20 0.41
MAPT P10636 1/20 0.41
TSHR P16473 1/20 0.40
HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12615992 0.85 ALDH1A1 (0.68) ALDH1A1NPSR1NOTUMKMT2AKDM4E
SCHEMBL14242848 0.76 ALDH1A1 (0.58) ALDH1A1NPSR1NOTUMKMT2AKDM4E
SCHEMBL5330184 0.76 ALDH1A1 (0.58) ALDH1A1NPSR1NOTUMKMT2AKDM4E
SCHEMBL20237265 0.76 ALDH1A1 (0.58) ALDH1A1NPSR1NOTUMKMT2AKDM4E
SCHEMBL28955008 0.76 ALDH1A1 (0.58) ALDH1A1NPSR1NOTUMKMT2AKDM4E
SCHEMBL8109135 0.76 ALDH1A1 (0.58) ALDH1A1NPSR1NOTUMKMT2AKDM4E
SCHEMBL5549180 0.76 ALDH1A1 (0.58) ALDH1A1NPSR1NOTUMKMT2AKDM4E
SCHEMBL30084182 0.76 ALDH1A1 (0.58) ALDH1A1NPSR1NOTUMKMT2AKDM4E
SCHEMBL436604 0.76 ALDH1A1 (0.58) ALDH1A1NPSR1NOTUMKMT2AKDM4E
SCHEMBL7768909 0.76 ALDH1A1 (0.58) ALDH1A1NPSR1NOTUMKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0797789-B1 NOVEL DIHYDRAZIDES AS DOT-PROMOTING AGENTS IN PHOTOGRAPHIC IMAGE SYSTEMS INT PAPER CO (US) 1998-11-25 EP disclosed
EP-0840614-A1 CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES SANOFI WINTHROP, INC. (US) 1998-05-13 EP disclosed
US-5702866-A SHARP IMAGES ILFORD A.G. (CH) 1997-12-30 US disclosed
US-5686222-A PHOTOGRAPHIC SILVER HALIDE EMULSION, DOT PROMOTING AGENTS ILFORD A.G. (CH) 1997-11-11 US disclosed
EP-0797789-A1 NOVEL DIHYDRAZIDES AS DOT-PROMOTING AGENTS IN PHOTOGRAPHIC IMAGE SYSTEMS ILFORD AG (CH) 1997-10-01 EP disclosed
EP-0752614-A2 Silver halide photographic light-sensitive material KONICA CORPORATION (JP) 1997-01-08 EP disclosed
WO-1996041638-A1 CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES SANOFI WINTHROP, INC. (US) 1996-12-27 WO disclosed
WO-1995032452-A1 NOVEL DIHYDRAZIDES AS DOT-PROMOTING AGENTS IN PHOTOGRAPHIC IMAGE SYSTEMS ILFORD AG (CH) 1995-11-30 WO disclosed