Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.81 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.56 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.56 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.56 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.56 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8536252 | 0.94 | LSS (0.72) | LSSMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1019998 | 0.79 | KDM4E (0.94) | MEN1KMT2AKDM4EALDH1A1SIGMAR1 | |
| SCHEMBL9645824 | 0.79 | KDM4E (0.94) | MEN1KMT2AKDM4EALDH1A1SIGMAR1 | |
| SCHEMBL8537662 | 0.79 | LMNA (0.64) | MEN1KMT2ASIGMAR1LMNATSHR | |
| SCHEMBL9363641 | 0.79 | HPGD (0.68) | LSSMEN1KMT2ACYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL9368954 | 0.78 | HPGD (0.66) | LSSMEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL4486386 | 0.77 | KDM4E (0.78) | MEN1KMT2AKDM4EALDH1A1SIGMAR1 | |
| SCHEMBL13149349 | 0.77 | KDM4E (0.78) | LSSMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8536306 | 0.76 | LSS (0.60) | LSSALDH1A1SIGMAR1CYP3A4 | |
| SCHEMBL8536314 | 0.76 | LSS (0.50) | LSSMEN1KMT2APRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537201-B1 | 1-[4-(IMIDAZOL-1-YL)BENZOYL]PIPERIDINE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | SCHERING AG (DE) | 1998-11-18 | — | — | EP | disclosed |
| EP-0537201-A1 | IMIDAZOLYLBENZOYL SUBSTITUTED HETEROCYCLES | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-04-21 | — | — | EP | disclosed |
| US-5189036-A | Cardiovascular agents; class III antiarrhythmic agents | SCHERING AG (DE) | 1993-02-23 | — | — | US | disclosed |
| WO-1991019709-A1 | IMIDAZOLYLBENZOYL SUBSTITUTED HETEROCYCLES | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1991-12-26 | — | — | WO | disclosed |