Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 12/20 | 0.66 |
| ▸ | EDNRA | P25101 | 11/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543285 | 0.94 | EDNRB (0.69) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL8545866 | 0.89 | EDNRA (0.66) | EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8545381 | 0.88 | EDNRA (0.53) | EDNRBEDNRA | |
| SCHEMBL8856691 | 0.86 | EDNRA (0.62) | EDNRBEDNRA | |
| SCHEMBL8541723 | 0.85 | EDNRB (0.57) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL6308654 | 0.84 | EDNRB (0.55) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL8592047 | 0.84 | EDNRB (0.59) | EDNRBEDNRA | |
| SCHEMBL8856802 | 0.81 | EDNRA (0.61) | EDNRBEDNRA | |
| SCHEMBL8590639 | 0.80 | EDNRA (0.64) | EDNRBEDNRA | |
| SCHEMBL8902860 | 0.80 | EDNRA (0.52) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800389-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-04-29 | — | — | EP | claimed |
| US-5684032-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC, ANTIASTHMATIC AGENTS AND RESPIRATORY DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-04 | — | — | US | claimed |
| EP-0800389-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-15 | — | — | EP | claimed |
| WO-1996018393-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-06-20 | — | — | WO | claimed |
| US-5684032-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC, ANTIASTHMATIC AGENTS AND RESPIRATORY DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |