Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 15/20 | 0.66 |
| ▸ | EDNRB | P24530 | 15/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540470 | 0.89 | EDNRB (0.66) | EDNRAEDNRBMEN1KMT2A | |
| SCHEMBL8543285 | 0.89 | EDNRB (0.69) | EDNRAEDNRBMEN1KMT2A | |
| SCHEMBL8856691 | 0.84 | EDNRA (0.62) | EDNRAEDNRB | |
| SCHEMBL8545381 | 0.82 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL8856802 | 0.81 | EDNRA (0.61) | EDNRAEDNRB | |
| SCHEMBL8541723 | 0.81 | EDNRB (0.57) | EDNRAEDNRBMEN1KMT2A | |
| SCHEMBL6308654 | 0.80 | EDNRB (0.55) | EDNRAEDNRBMEN1KMT2A | |
| SCHEMBL8590639 | 0.80 | EDNRA (0.64) | EDNRAEDNRB | |
| SCHEMBL8856895 | 0.79 | EDNRB (0.71) | EDNRAEDNRB | |
| SCHEMBL8857065 | 0.79 | EDNRA (0.55) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800389-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-04-29 | — | — | EP | claimed |
| US-5684032-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC, ANTIASTHMATIC AGENTS AND RESPIRATORY DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-04 | — | — | US | claimed |
| EP-0800389-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-15 | — | — | EP | claimed |
| WO-1996018393-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-06-20 | — | — | WO | claimed |
| US-5684032-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC, ANTIASTHMATIC AGENTS AND RESPIRATORY DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |