Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.60 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NAAA | Q02083 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TACR3 | P29371 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546498 | 0.90 | HPGD (0.65) | HPGDSMN1; SMN2NPC1TDP1CHRNB2 | |
| SCHEMBL8540196 | 0.88 | SMN1; SMN2 (0.70) | HPGDSMN1; SMN2NPC1TDP1CHRNB2 | |
| SCHEMBL8545138 | 0.86 | SMN1; SMN2 (0.67) | HPGDSMN1; SMN2NPC1TDP1CHRNB2 | |
| SCHEMBL8540059 | 0.83 | POLB (0.69) | HPGDSMN1; SMN2NPC1TDP1CHRNB2 | |
| SCHEMBL17646360 | 0.81 | ALDH1A1 (0.72) | HPGDSMN1; SMN2NPC1TDP1CHRNB2 | |
| SCHEMBL12849241 | 0.81 | HPGD (0.71) | HPGDSMN1; SMN2NPC1TDP1CHRNB2 | |
| SCHEMBL7311015 | 0.81 | ALDH1A1 (0.72) | HPGDSMN1; SMN2NPC1TDP1CHRNB2 | |
| SCHEMBL8540140 | 0.78 | HPGD (0.57) | HPGDSMN1; SMN2NPC1TDP1CHRNB2 | |
| SCHEMBL25432319 | 0.78 | NPC1 (0.93) | HPGDSMN1; SMN2NPC1TDP1ALDH1A1 | |
| SCHEMBL3700679 | 0.78 | NPC1 (1.00) | HPGDSMN1; SMN2NPC1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705258-B1 | AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY | KNOLL AG (DE) | 1998-12-30 | — | — | EP | disclosed |
| US-5741800-A | ANTIINFLAMMATORY AGENT, ANTIALLERGENS | KNOLL AKTIENGESELLACHAFT (DE) | 1998-04-21 | — | — | US | disclosed |
| EP-0705258-A1 | AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY | Knoll AG (DE) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000507-A1 | AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |