Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | NAAA | Q02083 | 1/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17646360 | 1.00 | ALDH1A1 (0.72) | ALDH1A1HPGDSMN1; SMN2POLBNPC1 | |
| SCHEMBL3919245 | 0.86 | RAB9A (0.67) | ALDH1A1HPGDSMN1; SMN2POLBRAB9A | |
| SCHEMBL22170868 | 0.86 | ALDH1A1 (0.68) | ALDH1A1HPGDSMN1; SMN2POLBNPC1 | |
| SCHEMBL12849241 | 0.83 | HPGD (0.71) | ALDH1A1HPGDSMN1; SMN2POLBNPC1 | |
| SCHEMBL27755645 | 0.83 | ALDH1A1 (0.56) | ALDH1A1HPGDSMN1; SMN2POLBNPC1 | |
| SCHEMBL1221986 | 0.82 | POLB (1.00) | HPGDSMN1; SMN2POLBNPC1TDP1 | |
| SCHEMBL8540196 | 0.82 | SMN1; SMN2 (0.70) | ALDH1A1HPGDSMN1; SMN2POLBNPC1 | |
| SCHEMBL17087869 | 0.82 | NPC1 (0.96) | HPGDSMN1; SMN2POLBNPC1TDP1 | |
| SCHEMBL6285963 | 0.82 | NPC1 (0.96) | HPGDSMN1; SMN2POLBNPC1TDP1 | |
| SCHEMBL8540522 | 0.81 | HPGD (0.68) | ALDH1A1HPGDSMN1; SMN2POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332464-B2 | Inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2022-05-17 | — | — | US | disclosed |
| EP-3512846-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |
| EP-0520336-A2 | Aldehyde derivatives and their use as calpain inhibitors | FUJIREBIO Inc. (JP) | 1992-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11332464-B2 | Inhibitors of lysine gingipain | ENPEP, PHYKPL, PREP | ALDH1A1 2355/4885HPGD 663/4885SMN1; SMN2 4659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.