SCHEMBL8545138

SCHEMBL8545138

O=C(CCc1ccccc1)N1CCCC(CCO)C1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.67
HPGD P15428 1/20 0.67
CHRNB2 P17787 4/20 0.62
CHRNA4 P43681 4/20 0.62
CHRNB4 P30926 3/20 0.62
CHRNA3 P32297 3/20 0.62
NPC1 O15118 2/20 0.61
TDP1 Q9NUW8 1/20 0.61
ALDH1A1 P00352 2/20 0.58
KDM4E B2RXH2 1/20 0.56
MAPK1 P28482 1/20 0.56
POLB P06746 1/20 0.54
NAAA Q02083 1/20 0.52
TSHR P16473 1/20 0.52
AKR1C3 P42330 1/20 0.51
FKBP1A P62942 1/20 0.50
CPB1 P15086 1/20 0.50
RAB9A P51151 1/20 0.49
CHRM2 P08172 1/20 0.47
CHRM4 P08173 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8540196 0.90 SMN1; SMN2 (0.70) SMN1; SMN2HPGDCHRNB2CHRNA4CHRNB4
SCHEMBL8546498 0.89 HPGD (0.65) SMN1; SMN2HPGDCHRNB2CHRNA4CHRNB4
SCHEMBL8540522 0.86 HPGD (0.68) SMN1; SMN2HPGDCHRNB2CHRNA4CHRNB4
SCHEMBL8540505 0.84 POLB (0.68) SMN1; SMN2HPGDCHRNB2CHRNA4CHRNB4
SCHEMBL20730320 0.83 CHRNB2 (0.51) SMN1; SMN2HPGDCHRNB2CHRNA4CHRNB4
SCHEMBL7311015 0.80 ALDH1A1 (0.72) SMN1; SMN2HPGDCHRNB2CHRNA4CHRNB4
SCHEMBL17646360 0.80 ALDH1A1 (0.72) SMN1; SMN2HPGDCHRNB2CHRNA4CHRNB4
SCHEMBL12849241 0.80 HPGD (0.71) SMN1; SMN2HPGDCHRNB2CHRNA4CHRNB4
SCHEMBL8546276 0.80 CPB1 (0.55) SMN1; SMN2HPGDCHRNB2CHRNA4CHRNB4
SCHEMBL6773162 0.79 SMN1; SMN2 (0.55) SMN1; SMN2NPC1AKR1C3RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0705258-B1 AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY KNOLL AG (DE) 1998-12-30 EP disclosed
US-5741800-A ANTIINFLAMMATORY AGENT, ANTIALLERGENS KNOLL AKTIENGESELLACHAFT (DE) 1998-04-21 US disclosed
EP-0705258-A1 AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY Knoll AG (DE) 1996-04-10 EP disclosed