Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 7/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 5/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8540329 | 0.74 | SLC6A3 (0.45) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL8546918 | 0.72 | GAA (0.38) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| Fumaric Acid SCHEMBL8547447 | 0.67 | SLC6A3 (0.43) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL15751917 | 0.66 | CCR5 (0.46) | CCR2KCNH2TACR2TACR1 | |
| SCHEMBL15751590 | 0.66 | CCR5 (0.46) | CCR2KCNH2TACR2TACR1 | |
| SCHEMBL8545710 | 0.65 | SLC6A2 (0.48) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| Hydrochloric Acid SCHEMBL8541267 | 0.64 | SLC6A2 (0.47) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| Hydrochloric Acid SCHEMBL8541270 | 0.64 | SLC6A2 (0.47) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL15751919 | 0.64 | TACR1 (0.54) | TACR2TACR1 | |
| SCHEMBL1421916 | 0.63 | TACR1 (0.45) | CCR2KCNH2TACR2TACR1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690842-B1 | 4-ARYLISOINDOLE ANALGESICS | ORTHO PHARMA CORP (US) | 1998-12-16 | — | — | EP | disclosed |
| US-5508424-A | REDUCED SIDE EFFECTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-04-16 | — | — | US | disclosed |