Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 9/20 | 0.45 |
| ▸ | SLC6A2 known ✓ | P23975 | 5/20 | 0.45 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8546918 | 0.84 | GAA (0.38) | SLC6A3SLC6A4SLC6A2 | |
| Fumaric Acid SCHEMBL8545846 | 0.83 | MEN1 (0.41) | SLC6A3SLC6A4SLC6A2HRH2 | |
| Fumaric Acid SCHEMBL8544579 | 0.82 | ALDH1A1 (0.37) | SLC6A3SLC6A4SLC6A2 | |
| Fumaric Acid SCHEMBL8546233 | 0.82 | HRH3 (0.36) | SLC6A3SLC6A4SLC6A2 | |
| Fumaric Acid SCHEMBL8541348 | 0.82 | HRH3 (0.36) | SLC6A3SLC6A4SLC6A2 | |
| Fumaric Acid SCHEMBL8543943 | 0.81 | HRH2 (0.46) | SLC6A3SLC6A4SLC6A2HRH2 | |
| Fumaric Acid SCHEMBL8547447 | 0.79 | SLC6A3 (0.43) | SLC6A3SLC6A4SLC6A2KCNH2 | |
| Fumaric Acid SCHEMBL8542175 | 0.76 | KDM4E (0.42) | — | |
| Fumaric Acid SCHEMBL8540901 | 0.76 | KDM4E (0.41) | — | |
| Oxalic Acid SCHEMBL8540602 | 0.74 | CCR2 (0.41) | SLC6A3SLC6A4SLC6A2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690842-B1 | 4-ARYLISOINDOLE ANALGESICS | ORTHO PHARMA CORP (US) | 1998-12-16 | — | — | EP | disclosed |
| US-5508424-A | REDUCED SIDE EFFECTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-04-16 | — | — | US | disclosed |
| WO-1994022823-A1 | 4-ARYLISOINDOLE ANALGESICS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-10-13 | — | — | WO | disclosed |