SCHEMBL8540668

SCHEMBL8540668

O=C(NC(=O)c1c(F)cccc1F)Nc1ccc(Oc2ccc(CF)cc2Cl)cc1F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
USP2 O75604 1/20 0.48
MAPT P10636 1/20 0.48
ALOX15 P16050 1/20 0.48
POLB P06746 1/20 0.42
PNLIP P16233 1/20 0.41
MET P08581 3/20 0.41
GCGR P47871 1/20 0.40
TLR8 Q9NR97 2/20 0.40
ATM Q13315 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 1/20 0.39
PYGL P06737 1/20 0.38
ALDH1A1 P00352 2/20 0.38
GAA P10253 1/20 0.38
MAPK14 Q16539 1/20 0.37
PARG Q86W56 1/20 0.37
TLR7 Q9NYK1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flufenoxuron SCHEMBL8407576 0.84 MEN1 (0.52) MEN1KMT2AUSP2MAPTALOX15
Flufenoxuron SCHEMBL29413952 0.84 MEN1 (0.52) MEN1KMT2AUSP2MAPTALOX15
Flufenoxuron SCHEMBL27798 0.84 MEN1 (0.52) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL9325616 0.83 MEN1 (0.51) MEN1KMT2AUSP2MAPTALOX15
Flufenoxuron SCHEMBL28899111 0.82 MEN1 (0.50) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL9326331 0.82 MEN1 (0.47) MEN1KMT2AUSP2MAPTALOX15
Flufenoxuron SCHEMBL8352196 0.82 MEN1 (0.48) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL9326313 0.81 MEN1 (0.53) MEN1KMT2AUSP2MAPTALOX15
Flufenoxuron SCHEMBL9274900 0.79 TLR8 (0.52) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL13620475 0.79 TLR8 (0.47) MEN1KMT2AUSP2MAPTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994395-A MIXTURE CONTAINING AN ACYLUREA AROMATIC COMPOUND AND ANTIBIOTIC NOVARTIS ANIMAL HEALTH US, INC. (US) 1999-11-30 US disclosed