SCHEMBL9326331

SCHEMBL9326331

N#Cc1ccc(Oc2ccc(NC(=O)NC(=O)NC(=O)c3c(F)cccc3F)c(F)c2)c(Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
USP2 O75604 1/20 0.46
MAPT P10636 1/20 0.46
ALOX15 P16050 1/20 0.46
POLB P06746 1/20 0.40
SCN9A Q15858 1/20 0.39
PNLIP P16233 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
GCGR P47871 1/20 0.39
FFAR1 O14842 1/20 0.38
TLR8 Q9NR97 1/20 0.38
MET P08581 1/20 0.38
BRAF P15056 1/20 0.37
KDR P35968 1/20 0.37
ATM Q13315 1/20 0.37
BRPF1 P55201 1/20 0.37
SIRT2 Q8IXJ6 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9325616 0.84 MEN1 (0.51) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL9326313 0.83 MEN1 (0.53) MEN1KMT2AUSP2MAPTALOX15
Flufenoxuron SCHEMBL29413952 0.82 MEN1 (0.52) MEN1KMT2AUSP2MAPTALOX15
Flufenoxuron SCHEMBL27798 0.82 MEN1 (0.52) MEN1KMT2AUSP2MAPTALOX15
Flufenoxuron SCHEMBL8407576 0.82 MEN1 (0.52) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL8540668 0.82 MEN1 (0.49) MEN1KMT2AUSP2MAPTALOX15
Flufenoxuron SCHEMBL28899111 0.81 MEN1 (0.50) MEN1KMT2AUSP2MAPTALOX15
Flufenoxuron SCHEMBL8352196 0.78 MEN1 (0.48) MEN1KMT2AUSP2MAPTALOX15
Flufenoxuron SCHEMBL9274900 0.77 TLR8 (0.52) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL13620475 0.76 TLR8 (0.47) MEN1KMT2AUSP2MAPTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0375069-B1 Benzamide compounds, their preparation and their use as pesticides SHELL INT RESEARCH (NL) 1994-03-09 EP disclosed
US-5155135-A Insecticides, miticides SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ, B.V. (NL) 1992-10-13 US disclosed
EP-0375069-A1 Benzamide compounds, their preparation and their use as pesticides SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1990-06-27 EP disclosed