Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 7/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | OGT | O15294 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546974 | 0.87 | GRIN2B (0.40) | GRIN2BGRIN1GRIN2DGRIN3BADRA1D | |
| SCHEMBL8549047 | 0.83 | GRIN1 (0.63) | GRIN2BGRIN1GRIN2DGRIN3BADRA1D | |
| SCHEMBL8541676 | 0.82 | GRIN2B (0.56) | GRIN2BALDH1A1LMNAOGT | |
| SCHEMBL8873886 | 0.82 | GRIN2B (0.54) | GRIN2BGRIN1HTR1ADRD2HTR2A | |
| SCHEMBL8547676 | 0.82 | GRIN2B (0.54) | GRIN2BGRIN1HTR1ADRD2HTR2A | |
| SCHEMBL8541881 | 0.81 | ALDH1A1 (0.58) | GRIN2BGRIN1HTR1ADRD2HTR2A | |
| SCHEMBL8873013 | 0.78 | LMNA (0.42) | GRIN2BALDH1A1LMNA | |
| SCHEMBL8543096 | 0.77 | GRIN2B (0.47) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL8545550 | 0.75 | GRIN1 (0.45) | GRIN2BGRIN1DRD2GRIN2DGRIN3B | |
| SCHEMBL8544337 | 0.75 | GRIN2B (0.57) | GRIN2BGRIN1GRIN2DGRIN3BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| US-5698553-A | Benzylpiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-16 | — | — | US | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |