Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2B | Q02880 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | BLM | P54132 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NSD2 | O96028 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MTOR | P42345 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | TOP2A | P11388 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.56 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544036 | 0.92 | TOP2B (0.54) | TOP2BMEN1BLMKMT2ALMNA | |
| SCHEMBL8544126 | 0.87 | CYP19A1 (0.54) | TOP2BMEN1BLMKMT2ALMNA | |
| SCHEMBL8544622 | 0.84 | KMT2A (0.61) | TOP2BMEN1BLMKMT2ALMNA | |
| SCHEMBL8539070 | 0.82 | TOP2B (0.42) | TOP2BMEN1BLMKMT2ALMNA | |
| SCHEMBL8540388 | 0.81 | ECE1 (0.45) | TOP2BMEN1BLMKMT2ALMNA | |
| Ametantrone SCHEMBL3344151 | 0.81 | TOP2B (1.00) | TOP2BMEN1BLMKMT2ALMNA | |
| Ametantrone SCHEMBL29723071 | 0.81 | TOP2B (1.00) | TOP2BMEN1BLMKMT2ALMNA | |
| SCHEMBL8547001 | 0.81 | TOP2B (0.41) | TOP2BMEN1BLMKMT2ALMNA | |
| Hydrochloric Acid SCHEMBL8539915 | 0.80 | TOP2B (0.40) | TOP2BMEN1BLMKMT2ALMNA | |
| Hydrochloric Acid SCHEMBL11041980 | 0.79 | TOP2B (0.97) | TOP2BMEN1BLMKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639183-B1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA (IT) | 1998-07-01 | — | — | EP | disclosed |
| WO-1992015566-A1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-09-17 | — | — | WO | disclosed |