Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | BLM | P54132 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | RECQL | P46063 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | NSD2 | O96028 | 3/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | TOP2A | P11388 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | EGFR | P00533 | 2/20 | 0.61 |
| ▸ | MTOR | P42345 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.61 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.61 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544790 | 0.87 | TOP2B (0.67) | KMT2AMEN1BLMLMNAMAPK1 | |
| SCHEMBL8543297 | 0.85 | MEN1 (0.51) | KMT2AMEN1BLMLMNAMAPK1 | |
| SCHEMBL8540909 | 0.84 | TOP2B (0.67) | KMT2AMEN1BLMLMNAMAPK1 | |
| SCHEMBL8541343 | 0.79 | ECE1 (0.38) | KMT2AMEN1BLMLMNAMAPK1 | |
| SCHEMBL8546215 | 0.77 | TOP2B (0.43) | KMT2AMEN1BLMSMN1; SMN2NSD2 | |
| SCHEMBL11391594 | 0.76 | MEN1 (1.00) | KMT2AMEN1BLMLMNAMAPK1 | |
| Mitoxantrone SCHEMBL20214110 | 0.76 | MEN1 (1.00) | KMT2AMEN1BLMLMNAMAPK1 | |
| SCHEMBL11036806 | 0.76 | MEN1 (1.00) | KMT2AMEN1BLMLMNAMAPK1 | |
| SCHEMBL11041207 | 0.76 | MEN1 (1.00) | KMT2AMEN1BLMLMNAMAPK1 | |
| SCHEMBL11517949 | 0.76 | MEN1 (1.00) | KMT2AMEN1BLMLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639183-B1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA (IT) | 1998-07-01 | — | — | EP | disclosed |
| EP-0639183-A1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1995-02-22 | — | — | EP | disclosed |
| WO-1992015566-A1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-09-17 | — | — | WO | disclosed |