Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 10/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525148 | 0.84 | CYP2D6 (0.56) | SIGMAR1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL2926465 | 0.84 | SIGMAR1 (0.55) | SIGMAR1HRH3CXCR4MEN1CHRM2 | |
| SCHEMBL8521055 | 0.76 | SIGMAR1 (0.47) | SIGMAR1HRH3CXCR4MEN1CHRM2 | |
| SCHEMBL27997744 | 0.76 | SIGMAR1 (0.47) | SIGMAR1HRH3CXCR4MEN1CHRM2 | |
| SCHEMBL19262611 | 0.74 | CYP3A4 (0.61) | SIGMAR1HRH3CXCR4MEN1CHRM2 | |
| SCHEMBL8525941 | 0.73 | SCN5A (0.43) | SIGMAR1HRH3ALDH1A1 | |
| SCHEMBL24627237 | 0.73 | SIGMAR1 (0.55) | SIGMAR1HRH3CXCR4MEN1CHRM2 | |
| SCHEMBL14614188 | 0.72 | ALDH1A1 (0.44) | HRH3MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL608181 | 0.71 | ALDH1A1 (0.70) | SIGMAR1CXCR4MEN1CHRM2KMT2A | |
| SCHEMBL29566534 | 0.71 | ALDH1A1 (0.70) | SIGMAR1CXCR4MEN1CHRM2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068450-A1 | CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2012-05-24 | — | — | WO | disclosed |