Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | BCL9 | O00512 | 2/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8532735 | 0.84 | KDM4E (0.48) | SIGMAR1HRH3PKMHPGDLSS | |
| SCHEMBL6121739 | 0.74 | ALDH1A1 (0.51) | ALDH1A1LMNA | |
| SCHEMBL16389289 | 0.74 | ALDH1A1 (0.41) | ALDH1A1LMNA | |
| SCHEMBL19404236 | 0.73 | CTNNB1 (0.53) | SIGMAR1BCL9CTNNB1 | |
| SCHEMBL8540980 | 0.73 | SIGMAR1 (0.44) | SIGMAR1HRH3ALDH1A1 | |
| SCHEMBL8577314 | 0.72 | SCN5A (0.49) | SCN5ASCN9ASIGMAR1PKMHPGD | |
| SCHEMBL24088883 | 0.72 | GABRD (0.52) | SIGMAR1PKMHPGDTDO2 | |
| SCHEMBL8545011 | 0.72 | JAK2 (0.43) | SCN5ASCN9APKMLSS | |
| SCHEMBL7904715 | 0.72 | HPGD (0.50) | HPGDALDH1A1LMNA | |
| SCHEMBL226167 | 0.70 | SIGMAR1 (0.56) | SIGMAR1HRH3PKMHPGDTDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068450-A1 | CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2012-05-24 | — | — | WO | disclosed |