SCHEMBL854222

SCHEMBL854222

N[C@@H](Cc1ccccc1)C(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 7/20 0.70
ADORA2A P29274 6/20 0.70
ADORA1 P30542 5/20 0.70
TSHR P16473 3/20 0.70
NFKB1 P19838 3/20 0.70
TP53 P04637 2/20 0.70
ALDH1A1 P00352 2/20 0.70
PMP22 Q01453 2/20 0.70
NPC1 O15118 2/20 0.70
RAB9A P51151 2/20 0.70
RXFP1 Q9HBX9 2/20 0.70
ADORA2B P29275 2/20 0.70
CYP3A4 P08684 1/20 0.70
ALOX12 P18054 1/20 0.70
HIF1A Q16665 1/20 0.70
HPGD P15428 1/20 0.70
SLC29A1 Q99808 2/20 0.67
TDP1 Q9NUW8 1/20 0.67
THPO P40225 2/20 0.65
NPEPPS P55786 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL855679 0.92 SLC29A1 (0.61) ADORA3ADORA2AADORA1TSHRNFKB1
SCHEMBL4125974 0.88 P2RY12 (0.72) ADORA1SMN1; SMN2
SCHEMBL30208574 0.88 LMNA (0.60) ADORA3ADORA2AADORA1TSHRNFKB1
SCHEMBL30208537 0.86 LMNA (0.58) ADORA3ADORA2AADORA1TSHRNFKB1
SCHEMBL30208584 0.86 ADORA2A (0.59) ADORA3ADORA2AADORA1ALDH1A1PMP22
SCHEMBL20626159 0.85 ADORA3 (0.79) ADORA3ADORA2AADORA1TSHRNFKB1
SCHEMBL20626158 0.85 ADORA3 (0.79) ADORA3ADORA2AADORA1TSHRNFKB1
SCHEMBL20626186 0.85 ADORA3 (0.79) ADORA3ADORA2AADORA1TSHRNFKB1
SCHEMBL14713382 0.85 ADORA3 (0.79) ADORA3ADORA2AADORA1TSHRNFKB1
SCHEMBL14713386 0.85 ADORA3 (0.79) ADORA3ADORA2AADORA1TSHRNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240327822-A1 MATERIALS AND METHODS TO COMPREHENSIVELY DEFINE ADAPTIVE IMMUNE RESPONSES THE UNIVERSITY OF HONG KONG (CN) 2024-10-03 US claimed
EP-4384614-A1 MATERIALS AND METHODS TO COMPREHENSIVELY DEFINE ADAPTIVE IMMUNE RESPONSES The University of Hong Kong (HK) 2024-06-19 EP claimed
CN-118176298-A Materials and methods for comprehensive definition of adaptive immune responses 香港大学 2024-06-11 CN claimed
WO-2023016454-A1 MATERIALS AND METHODS TO COMPREHENSIVELY DEFINE ADAPTIVE IMMUNE RESPONSES THE UNIVERSITY OF HONG KONG (CN) 2023-02-16 WO claimed
EP-2316030-B1 PROTEIN SCREEING METHODS WAGNER RICHARD W (US) 2019-08-21 EP claimed
US-9803193-B2 Protein screening methods X-BODY, INC. (US) 2017-10-31 US claimed
US-9134304-B2 Protein screening methods X-BODY, INC. (US) 2015-09-15 US claimed
US-20140128275-A1 COMPLEX OF NON-COVALENTLY BOUND PROTEIN WITH ENCODING NUCLEIC ACIDS AND USES THEREOF Syndecion, LLC (US) 2014-05-08 US claimed
US-8207093-B2 Producing libraries; including high salt post translational incubation step THE GENERAL HOSPITAL CORPORATION (US) 2012-06-26 US claimed
EP-1712623-B1 Selection of proteins using RNA-protein fusions GEN HOSPITAL CORP (US) 2011-10-19 EP claimed
US-6207446-B1 MICROCHIP ARRAY OF IMMOBILIZED SINGLE-STRANDED NUCLEIC ACIDS WHICH ARE HYBRIDIZED TO RNA-PROTEIN FUSIONS; FUSIONS ARE RNA COVALENTLY BONDED TO 3' END OF PROTEIN THROUGH A PEPTIDE ACCEPTOR; PROTEIN IS ENCODED BY RNA; CYCLES OF SCREENING THE GENERAL HOSPITAL CORPORATION 2001-03-27 US claimed
EP-3775261-B1 TARGET BINDING MOIETY COMPOSITIONS AND METHODS OF USE GUANGZHOU CHENGYUAN BIOIMMUNOLOGY TECH CO LTD (CN) 2025-09-17 EP disclosed
US-12116572-B2 Target binding moiety compositions and methods of use Guangzhou Chengyuan Bioimmunology Technology Co., Ltd. (CN) 2024-10-15 US disclosed
US-20240327822-A1 MATERIALS AND METHODS TO COMPREHENSIVELY DEFINE ADAPTIVE IMMUNE RESPONSES THE UNIVERSITY OF HONG KONG (CN) 2024-10-03 US disclosed
EP-4384614-A1 MATERIALS AND METHODS TO COMPREHENSIVELY DEFINE ADAPTIVE IMMUNE RESPONSES The University of Hong Kong (HK) 2024-06-19 EP disclosed
WO-2001007657-A1 PEPTIDE ACCEPTOR LIGATION METHODS PHYLOS, INC. (US) 2001-02-01 WO disclosed
WO-2000047775-A1 SELECTION OF PROTEINS USING RNA-PROTEIN FUSIONS THE GENERAL HOSPITAL CORPORATION (US) 2000-08-17 WO disclosed
CN-1251593-A Selection of proteins using RNA-protein fusions GEN HOSPITAL CORP (US) 2000-04-26 CN disclosed
EP-0971946-A1 SELECTION OF PROTEINS USING RNA-PROTEIN FUSIONS THE GENERAL HOSPITAL CORPORATION (US) 2000-01-19 EP disclosed
WO-1998031700-A1 SELECTION OF PROTEINS USING RNA-PROTEIN FUSIONS THE GENERAL HOSPITAL CORPORATION (US) 1998-07-23 WO disclosed