Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.55 |
| ▸ | CCR5 | P51681 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MAOB | P27338 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31538745 | 0.88 | ALOX5 (0.57) | ALOX5CCR5MAPTMAOBMEN1 | |
| SCHEMBL8544483 | 0.85 | ALOX5 (0.50) | ALOX5CCR5MAPTMAOBMEN1 | |
| SCHEMBL8544488 | 0.85 | ALOX5 (0.50) | ALOX5CCR5MAPTMAOBMEN1 | |
| SCHEMBL8544470 | 0.83 | ALOX5 (0.47) | ALOX5CCR5MAPTMAOBMEN1 | |
| SCHEMBL8544473 | 0.83 | ALOX5 (0.47) | ALOX5CCR5MAPTMAOBMEN1 | |
| SCHEMBL8548850 | 0.80 | ALOX5 (0.50) | ALOX5CCR5MAPTMAOBMAOA | |
| SCHEMBL8548854 | 0.80 | ALOX5 (0.50) | ALOX5CCR5MAPTMAOBMAOA | |
| SCHEMBL3499773 | 0.80 | CCR5 (0.53) | ALOX5CCR5MAPTMAOBMEN1 | |
| SCHEMBL9058393 | 0.80 | ALOX5 (0.67) | ALOX5MAPTMAOBMEN1KMT2A | |
| SCHEMBL9730986 | 0.80 | ALOX5 (0.64) | ALOX5NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591046-B1 | Chromene derivatives with a triene chain for use in the treatment of osteoporosis inflammatory diseases | ADIR (FR) | 1998-12-02 | — | — | EP | disclosed |
| US-5391569-A | Treating osteoporosis, inflammatory disorders | ADIR ET COMPAGNIE (FR) | 1995-02-21 | — | — | US | disclosed |
| EP-0591046-A1 | Chromene derivatives with a triene chain for use in the treatment of osteoporosis inflammatory diseases | ADIR ET COMPAGNIE (FR) | 1994-04-06 | — | — | EP | disclosed |