Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545197 | 0.86 | ERN1 (0.35) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8545252 | 0.83 | ALDH1A1 (0.30) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8548094 | 0.82 | KDM4E (0.39) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8545260 | 0.78 | MAPT (0.41) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL9023793 | 0.71 | ALDH1A1 (0.41) | KDM4EALDH1A1MAPTHPGDLMNA | |
| SCHEMBL8539652 | 0.70 | ERO1A (0.33) | KDM4EMEN1ALDH1A1MAPTAPEX1 | |
| SCHEMBL8543080 | 0.68 | MAPT (0.35) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8546612 | 0.67 | HTR2A (0.32) | KMT2A | |
| SCHEMBL8547454 | 0.67 | SMN1; SMN2 (0.30) | — | |
| SCHEMBL9233446 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0487097-B1 | Pyrazoloacridone derivatives | KYOWA HAKKO KOGYO KK (JP) | 1998-10-14 | — | — | EP | disclosed |
| US-5220026-A | Antitumor agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-06-15 | — | — | US | disclosed |
| EP-0487097-A1 | Pyrazoloacridone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-05-27 | — | — | EP | disclosed |