Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023798 | 0.83 | MAPT (0.41) | ALDH1A1KDM4ELMNAMAPTHSD17B10 | |
| SCHEMBL8545260 | 0.82 | MAPT (0.41) | ALDH1A1KDM4ELMNAMAPTHSD17B10 | |
| SCHEMBL9023936 | 0.81 | NQO2 (0.34) | ALDH1A1MAPTCYP1A2PARP1HTT | |
| SCHEMBL9025389 | 0.81 | KDM1A (0.41) | ALDH1A1KDM4ELMNAMAPTHSD17B10 | |
| SCHEMBL8543080 | 0.80 | MAPT (0.35) | ALDH1A1KDM4ELMNAMAPTHSD17B10 | |
| SCHEMBL9025371 | 0.79 | CYP1A2 (0.44) | ALDH1A1KDM4ELMNAMAPTHSD17B10 | |
| SCHEMBL8548094 | 0.78 | KDM4E (0.39) | ALDH1A1KDM4ELMNAMAPTNPC1 | |
| SCHEMBL9025257 | 0.77 | KDM4E (0.40) | ALDH1A1KDM4ELMNAMAPTHSD17B10 | |
| SCHEMBL9024798 | 0.75 | NQO2 (0.56) | ALDH1A1KDM4ELMNANQO1NQO2 | |
| SCHEMBL9023664 | 0.74 | KDM4E (0.45) | KDM4ELMNAMAPTTP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| EP-0347749-A2 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |