Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYB | P10242 | 14/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9343227 | 0.84 | MYB (0.70) | MYBMAPTALDH1A1LNPEPCYP1A2 | |
| SCHEMBL8542128 | 0.83 | MYB (1.00) | MYBMAPTALDH1A1CYP1A2KDM4E | |
| SCHEMBL8538496 | 0.83 | MYB (0.48) | MYBMAPTCYP1A2KDM4EGAA | |
| SCHEMBL10275382 | 0.79 | MYB (0.74) | MYBMAPTALDH1A1LNPEPCYP1A2 | |
| SCHEMBL10275379 | 0.79 | MYB (0.74) | MYBMAPTALDH1A1LNPEPCYP1A2 | |
| SCHEMBL8810542 | 0.79 | MYB (0.74) | MYBMAPTALDH1A1LNPEPCYP1A2 | |
| SCHEMBL1752053 | 0.77 | MYB (0.70) | MYBMAPTALDH1A1LNPEPCYP1A2 | |
| SCHEMBL8543623 | 0.76 | MYB (0.66) | MYBMAPTALDH1A1KDM4EGAA | |
| SCHEMBL8543620 | 0.76 | MYB (0.66) | MYBMAPTALDH1A1KDM4EGAA | |
| SCHEMBL8538222 | 0.75 | MYB (0.61) | MYBMAPTALDH1A1CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537949-B1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY CO ELI (GB) | 1998-07-01 | — | — | EP | disclosed |
| US-5284868-A | Naphthopyran derivatives; for autoimmune diseases, cancer | ELI LILLY AND COMPANY (US) | 1994-02-08 | — | — | US | disclosed |
| US-5281619-A | Administering naphtho(1,2-B)pyran derivatives | ELI LILLY AND COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0537949-A1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY INDUSTRIES LIMITED (GB) | 1993-04-21 | — | — | EP | disclosed |