Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CAD | P27708 | 2/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6346374 | 1.00 | EGLN1 (0.47) | EGLN1GRIA2CYP2D6ALOX15CYP1A2 | |
| SCHEMBL1300246 | 0.74 | — | — | |
| SCHEMBL690090 | 0.74 | — | — | |
| SCHEMBL690089 | 0.74 | — | — | |
| SCHEMBL4453517 | 0.72 | CAD (0.42) | EGLN1GRIA2CYP2D6ALOX15CYP1A2 | |
| SCHEMBL6950284 | 0.72 | — | — | |
| SCHEMBL16467758 | 0.72 | CAD (0.48) | EGLN1GRIA2CYP2D6ALOX15CYP1A2 | |
| SCHEMBL190463 | 0.68 | — | — | |
| SCHEMBL635259 | 0.68 | — | — | |
| SCHEMBL7422071 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58110573-A | — | — | None | — | — | JP | disclosed |
| CN-109678852-B | 6-oxo-hexahydropyrimidine derivative, preparation method and pharmaceutical application thereof | 南京中医药大学 | 2022-04-19 | — | — | CN | disclosed |
| CN-109678852-A | 6- oxo hexahydropyrimidine derivative, preparation method and pharmacy application | 南京中医药大学 | 2019-04-26 | — | — | CN | disclosed |
| EP-0442473-B1 | Pyrimidinedione derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-08-19 | — | — | EP | disclosed |
| JP-S58110573-A | HEXAHYDRO-6-OXO-4-PYRIMIDINECARBOXYLIC ACID DERIVATIVE | OTSUKA PHARMACEUT FACTORY INC | 1983-07-01 | — | — | JP | disclosed |