Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.51 |
| ▸ | DRD2 | P14416 | 6/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.48 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326100 | 0.81 | HTR1A (0.51) | HTR1ADRD2SLC6A4DRD4 | |
| SCHEMBL9326213 | 0.81 | HTR1A (0.47) | HTR1ADRD2SLC6A4DRD4 | |
| SCHEMBL11270603 | 0.77 | DRD2 (0.57) | HTR1ADRD2HTR2AHTTDRD4 | |
| Hydrochloric Acid SCHEMBL11193593 | 0.77 | DRD2 (0.57) | HTR1ADRD2HTR2AHTTDRD4 | |
| SCHEMBL7805127 | 0.77 | CYP2D6 (0.58) | HTR1ADRD2HTR2AHTTDRD4 | |
| SCHEMBL6042752 | 0.76 | DRD2 (0.63) | HTR1ADRD2HTR2AHTTDRD4 | |
| SCHEMBL6043002 | 0.75 | DRD2 (0.59) | HTR1ADRD2HTR2AHTTDRD4 | |
| SCHEMBL2395487 | 0.75 | DRD2 (0.59) | HTR1ADRD2HTR2AHTTDRD4 | |
| SCHEMBL615291 | 0.74 | DRD2 (0.47) | HTR1ADRD2HTR2AHTTDRD4 | |
| SCHEMBL8142426 | 0.74 | DRD2 (0.47) | HTR1ADRD2HTR2AHTTDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5242933-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-09-07 | — | — | US | claimed |
| EP-0711291-B1 | N-(PIPERIDINYL-1-ALKYL)-SUBSTITUTED CYCLOHEXANE CARBOXYLIC ACID AMIDES AS 5-HT1A RECEPTOR ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 1998-11-25 | — | — | EP | disclosed |
| US-5763460-A | N-(piperidinyl-1-alkyl)-substituted cyclohexane carboxylic acid amides as 5-htia receptor antagonists | JOHN WYETH & BROTHER LIMITED (US) | 1998-06-09 | — | — | US | disclosed |
| US-5292761-A | Piperidine, tetrahydropyridine and pyrrolidine compounds | ADIR ET COMPAGNIE (FR) | 1994-03-08 | — | — | US | disclosed |
| US-5278185-A | Piperidine, Tetrahydropyridine and pyrrolidine compounds | ADIR ET COMPAGNIE (FR) | 1994-01-11 | — | — | US | disclosed |
| US-5260317-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-11-09 | — | — | US | disclosed |
| US-5250544-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-10-05 | — | — | US | disclosed |
| US-5242933-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-09-07 | — | — | US | disclosed |
| US-5240942-A | Hypotensive agents; 5-hydroxytryptamine antagonist | ADIR ET COMPAGNIE (FR) | 1993-08-31 | — | — | US | disclosed |