Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326213 | 0.81 | HTR1A (0.47) | HTR1ASLC6A4DRD2DRD4 | |
| SCHEMBL8544064 | 0.81 | HTR1A (0.51) | HTR1ASLC6A4DRD2DRD4 | |
| SCHEMBL9444705 | 0.75 | HTR1A (0.64) | HTR1ASLC6A4DRD4 | |
| Hydrochloric Acid SCHEMBL9323890 | 0.75 | HTR1A (0.64) | HTR1ASLC6A4DRD4 | |
| SCHEMBL6610951 | 0.74 | HTR1A (0.64) | HTR1ASLC6A4 | |
| SCHEMBL9030293 | 0.74 | HTR1D (0.52) | HTR1ASLC6A4DRD2 | |
| SCHEMBL6591284 | 0.73 | DRD2 (0.59) | HTR1ASLC6A4DRD2 | |
| SCHEMBL6594841 | 0.73 | HTR1A (0.68) | HTR1ASLC6A4DRD2DRD4 | |
| SCHEMBL6589336 | 0.73 | DRD2 (0.59) | HTR1ASLC6A4DRD2 | |
| SCHEMBL11828531 | 0.73 | HTR1A (0.47) | HTR1ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374772-A | Skin disorders, antiinflammatory agents, cardiovascular disorders | HOFFMANN-LAROCHE INC. (US) | 1994-12-20 | — | — | US | disclosed |
| EP-0601385-A1 | Disubstituted benzoic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |
| US-5292761-A | Piperidine, tetrahydropyridine and pyrrolidine compounds | ADIR ET COMPAGNIE (FR) | 1994-03-08 | — | — | US | disclosed |
| US-5278185-A | Piperidine, Tetrahydropyridine and pyrrolidine compounds | ADIR ET COMPAGNIE (FR) | 1994-01-11 | — | — | US | disclosed |
| US-5260317-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-11-09 | — | — | US | disclosed |
| US-5250544-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-10-05 | — | — | US | disclosed |
| US-5242933-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-09-07 | — | — | US | disclosed |
| US-5240942-A | Hypotensive agents; 5-hydroxytryptamine antagonist | ADIR ET COMPAGNIE (FR) | 1993-08-31 | — | — | US | disclosed |
| EP-0466585-A1 | Novel piperidin, tetrahydropyridine and pyrrolidine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-01-15 | — | — | EP | disclosed |