Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 5/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537545 | 0.90 | CYP3A4 (0.47) | TBXAS1CYP3A4 | |
| SCHEMBL8544402 | 0.89 | TBXAS1 (0.56) | TBXAS1PLA2G4A | |
| SCHEMBL8538159 | 0.88 | TBXAS1 (0.50) | TBXAS1CNR2LTA4HPLA2G4AHDAC3 | |
| Trifluoroacetic Acid SCHEMBL9221603 | 0.87 | TBXAS1 (0.55) | TBXAS1PLA2G4A | |
| Trifluoroacetic Acid SCHEMBL9034373 | 0.84 | TBXAS1 (0.49) | TBXAS1CNR2LTA4HPLA2G4AHDAC3 | |
| SCHEMBL8544695 | 0.83 | TRPM5 (0.40) | TBXAS1CNR2LTA4HCYP3A4CNR1 | |
| SCHEMBL8544039 | 0.83 | TBXAS1 (0.52) | TBXAS1CNR2LTA4HHDAC3HDAC1 | |
| SCHEMBL8543141 | 0.82 | TBXAS1 (0.46) | TBXAS1CNR2LTA4HKDM4ELMNA | |
| SCHEMBL8541177 | 0.82 | TBXAS1 (0.54) | TBXAS1LTA4H | |
| SCHEMBL8543283 | 0.80 | TBXAS1 (0.51) | TBXAS1CNR2CNR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | disclosed |
| EP-0715627-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | Pfizer Limited (GB) | 1996-06-12 | — | — | EP | disclosed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | disclosed |