Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | CTSB | P07858 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | TDO2 | P48775 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544750 | 0.78 | POLB (0.45) | POLBALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL2312934 | 0.77 | POLB (0.50) | POLBALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL31067269 | 0.77 | POLB (0.61) | POLBALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL10844067 | 0.77 | POLB (0.61) | POLBALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL5865341 | 0.77 | HSP90AA1 (0.67) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL10464631 | 0.76 | DHODH (0.49) | ALDH1A1MAPTKDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL7243262 | 0.75 | MEN1 (0.62) | ALDH1A1KDM4EKMT2AMEN1CASP6 | |
| SCHEMBL7812084 | 0.75 | MAPT (0.67) | POLBALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL10945219 | 0.75 | CASP6 (0.62) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL27242758 | 0.74 | MAPT (0.65) | POLBALDH1A1MAPTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581500-B1 | Antibiotic carbapenem compounds | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5441949-A | Carbapenem antibiotic compounds | ZENECA LIMITED (GB) | 1995-08-15 | — | — | US | disclosed |
| EP-0581500-A1 | Antibiotic carbapenem compounds | ZENECA LIMITED (GB) | 1994-02-02 | — | — | EP | disclosed |