SCHEMBL854481

SCHEMBL854481

O=C1OCc2cc(F)c(F)cc21

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.53
MAPT P10636 2/20 0.50
LMNA P02545 2/20 0.50
GAA P10253 1/20 0.50
PRF1 P14222 4/20 0.49
MAOA P21397 5/20 0.48
MAOB P27338 5/20 0.48
RECQL P46063 1/20 0.44
ALDH1A1 P00352 4/20 0.43
KDM4E B2RXH2 2/20 0.43
PKM P14618 1/20 0.43
TYMS P04818 1/20 0.41
CYP1A2 P05177 1/20 0.41
HPGD P15428 1/20 0.41
CYP2C19 P33261 1/20 0.41
HSD17B10 Q99714 1/20 0.41
PPIA P62937 1/20 0.41
KCNJ1 P48048 1/20 0.40
KCNH2 Q12809 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL854918 0.84 CYP3A4 (0.47) CYP3A4MAPTLMNAGAAPRF1
SCHEMBL9732073 0.84 MAPT (0.53) CYP3A4MAPTLMNAGAAPRF1
SCHEMBL29559672 0.84 MAPT (0.53) CYP3A4MAPTLMNAGAAPRF1
SCHEMBL20570609 0.84 CYP3A4 (0.47) CYP3A4MAPTLMNAGAAPRF1
SCHEMBL13412837 0.84 CYP3A4 (0.63) CYP3A4MAPTLMNAGAAPRF1
SCHEMBL25236292 0.80 KCNJ1 (0.52) CYP3A4MAPTLMNAGAAPRF1
SCHEMBL24355951 0.79 CYP3A4 (0.42) CYP3A4MAPTLMNAGAAPRF1
SCHEMBL2729075 0.76 CYP3A4 (0.41) CYP3A4MAPTLMNAGAAPRF1
SCHEMBL26774121 0.76 MAPT (0.41) CYP3A4MAPTLMNAGAAPRF1
SCHEMBL856120 0.75 MAOB (0.62) CYP3A4MAPTLMNAGAAMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12435075-B2 Compound, film, sensor, and electronic device SAMSUNG ELECTRONICS CO., LTD. (KR) 2025-10-07 US disclosed
EP-3689868-B1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ARVINAS OPERATIONS INC (US) 2023-09-27 EP disclosed
EP-4174063-A1 COMPOUND, FILM, SENSOR, AND ELECTRONIC DEVICE Samsung Electronics Co., Ltd. (KR) 2023-05-03 EP disclosed
CN-116023369-A Compound, membrane, sensor and electronic device 三星电子株式会社 2023-04-28 CN disclosed
US-20230125778-A1 COMPOUND, FILM, SENSOR, AND ELECTRONIC DEVICE SAMSUNG ELECTRONICS CO., LTD. (KR) 2023-04-27 US disclosed
US-20230125778-A1 COMPOUND, FILM, SENSOR, AND ELECTRONIC DEVICE SAMSUNG ELECTRONICS CO., LTD. (KR) 2023-04-27 US disclosed
US-20220388984-A1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ARVINAS OPERATIONS, INC. 2022-12-08 US disclosed
US-20220267305-A1 MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2022-08-25 US disclosed
US-20210139458-A1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ARVINAS OPERATIONS, INC. 2021-05-13 US disclosed
CN-105712945-B 2-substituted oxy-5-methylsulfonyl aryl piperazine amide analogue and preparation method and application thereof 上海翰森生物医药科技有限公司 2020-12-01 CN disclosed
US-20200199107-A1 MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE Arvinas, Inc. 2020-06-25 US disclosed
US-10604506-B2 Modulators of estrogen receptor proteolysis and associated methods of use ARVINAS OPERATIONS, INC. (US) 2020-03-31 US disclosed
WO-2018140809-A1 MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE Arvinas, Inc. (US) 2018-08-02 WO disclosed
WO-2018102725-A1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS Arvinas, Inc. (US) 2018-06-07 WO disclosed
US-20180155322-A1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ARVINAS OPERATIONS, INC. 2018-06-07 US disclosed
CN-105849094-B The manufacture method of halogen-substituted phthalein 住友化学株式会社 2018-04-10 CN disclosed
CN-105712945-A 2-Substituted-oxy-5-methylsulfonyl aryl piperazine acidamide analogue and preparation method and application thereof 上海翰森生物医药科技有限公司 2016-06-29 CN disclosed
US-8604221-B2 Production method of halogen-substituted phthalide SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-12-10 US disclosed
US-20120142946-A1 PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-06-07 US disclosed
EP-2433933-A1 PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE Sumitomo Chemical Company, Limited (JP) 2012-03-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10604506-B2 Modulators of estrogen receptor proteolysis and associated methods of use ADRM1, MDM2, ESR2 CYP3A4 4408/4885MAPT 2402/4885LMNA 2487/4885
US-20210139458-A1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS MDM2, CRBN, VHL CYP3A4 2896/4885MAPT 2558/4885LMNA 2706/4885
US-20230125778-A1 COMPOUND, FILM, SENSOR, AND ELECTRONIC DEVICE HAX1, CYP19A1, ESR1 CYP3A4 481/4885MAPT 3060/4885LMNA 2988/4885
US-20220388984-A1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS MDM2, CRBN, VHL CYP3A4 2896/4885MAPT 2558/4885LMNA 2706/4885
US-20200199107-A1 MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE ADRM1, MDM2, ESR2 CYP3A4 4408/4885MAPT 2402/4885LMNA 2487/4885
US-20220267305-A1 MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE ADRM1, MDM2, ESR2 CYP3A4 4408/4885MAPT 2402/4885LMNA 2487/4885
US-20180155322-A1 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS MDM2, CRBN, VHL CYP3A4 2896/4885MAPT 2558/4885LMNA 2706/4885
US-12435075-B2 Compound, film, sensor, and electronic device HAX1, CYP19A1, ESR1 CYP3A4 481/4885MAPT 3060/4885LMNA 2988/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.