SCHEMBL854918

SCHEMBL854918

O=C1OCc2cc(Br)c(F)cc21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.47
MAPT P10636 2/20 0.44
LMNA P02545 2/20 0.44
GAA P10253 1/20 0.44
MAOA P21397 8/20 0.42
MAOB P27338 8/20 0.42
ALDH1A1 P00352 4/20 0.42
KDM4E B2RXH2 2/20 0.40
RECQL P46063 1/20 0.40
PRF1 P14222 1/20 0.40
PKM P14618 1/20 0.40
ABCC9 O60706 1/20 0.39
ABCC8 Q09428 1/20 0.39
KCNJ11 Q14654 1/20 0.39
KCNJ8 Q15842 1/20 0.39
PPIA P62937 1/20 0.38
TYMS P04818 1/20 0.37
CYP1A2 P05177 1/20 0.37
HPGD P15428 1/20 0.37
CYP2C19 P33261 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20570609 0.93 CYP3A4 (0.47) CYP3A4MAPTLMNAGAAMAOA
SCHEMBL854481 0.84 CYP3A4 (0.53) CYP3A4MAPTLMNAGAAMAOA
SCHEMBL855514 0.84 CYP3A4 (0.53) CYP3A4MAPTLMNAGAAMAOA
SCHEMBL854665 0.78 CYP3A4 (0.47) CYP3A4MAPTLMNAGAAMAOA
SCHEMBL32666728 0.78 CYP3A4 (0.47) CYP3A4MAPTLMNAGAAMAOA
SCHEMBL2732842 0.78 CYP3A4 (0.51) CYP3A4MAPTLMNAGAAMAOA
SCHEMBL30591654 0.78 CYP3A4 (0.47) CYP3A4MAPTLMNAGAAMAOA
SCHEMBL21776729 0.78 MAPT (0.53) CYP3A4MAPTLMNAGAAMAOA
SCHEMBL2729424 0.78 CYP3A4 (0.47) CYP3A4MAPTLMNAGAAMAOA
SCHEMBL27094979 0.78 CYP3A4 (0.47) CYP3A4MAPTLMNAGAAMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116457344-B Low molecular weight protein degradation agent and application thereof 凯普托尔治疗学股份有限公司 2026-05-12 CN disclosed
EP-4630414-A1 TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN Captor Therapeutics S.A. (PL) 2025-10-15 EP disclosed
WO-2025061148-A1 HETEROARYL COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE 江苏恒瑞医药股份有限公司 2025-03-27 WO disclosed
WO-2025049746-A1 COMPOSITIONS COMPRISING WERNER SYNDROME HELICASE INHIBITORS AND METHODS OF USING THE SAME EIKON THERAPEUTICS, INC. (US) 2025-03-06 WO disclosed
US-20240294489-A1 LOW MOLECULAR WEIGHT PROTEIN DEGRADERS AND THEIR APPLICATIONS CAPTOR THERAPEUTICS S.A. (PL) 2024-09-05 US disclosed
WO-2024121256-A1 TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN CAPTOR THERAPEUTICS S.A. (PL) 2024-06-13 WO disclosed
CN-116457344-A Low molecular weight protein degradation agent and application thereof 凯普托尔治疗学股份有限公司 2023-07-18 CN disclosed
EP-4188373-A1 LOW MOLECULAR WEIGHT PROTEIN DEGRADERS AND THEIR APPLICATIONS Captor Therapeutics S.A. (PL) 2023-06-07 EP disclosed
WO-2022029138-A1 LOW MOLECULAR WEIGHT PROTEIN DEGRADERS AND THEIR APPLICATIONS CAPTOR THERAPEUTICS S.A. (PL) 2022-02-10 WO disclosed
US-8604221-B2 Production method of halogen-substituted phthalide SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-12-10 US disclosed
US-20120142946-A1 PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-06-07 US disclosed
EP-2433933-A1 PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE Sumitomo Chemical Company, Limited (JP) 2012-03-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240294489-A1 LOW MOLECULAR WEIGHT PROTEIN DEGRADERS AND THEIR APPLICATIONS MMP2, PSME2, PSME1 CYP3A4 2913/4885MAPT 3551/4885LMNA 2945/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.