Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.38 |
| ▸ | HTR1A | P08908 | 8/20 | 0.36 |
| ▸ | HTR1B | P28222 | 8/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 6/20 | 0.30 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549571 | 0.94 | HTR1B (0.37) | CSNK2A1HTR1AHTR1BMAPTHTR1D | |
| SCHEMBL8548477 | 0.84 | HTR1A (0.42) | CSNK2A1HTR1AGPR84HTR2A | |
| SCHEMBL8549160 | 0.81 | HTR2A (0.45) | CSNK2A1HTR1AHTR1BMAPTHTR1D | |
| SCHEMBL8543442 | 0.81 | HTR1A (0.54) | CSNK2A1HTR1AHTR1BMAPTHTR1D | |
| SCHEMBL8549558 | 0.80 | HTR2A (0.45) | CSNK2A1MAPTHTR1DHTR2AKDM4E | |
| SCHEMBL8543561 | 0.80 | HTR2A (0.46) | HTR1AHTR1BHTR1DHTR2AALDH1A1 | |
| SCHEMBL8545081 | 0.79 | HTR1A (0.55) | HTR1AHTR1BL3MBTL1HTR1DHTR2A | |
| SCHEMBL8869470 | 0.77 | CSNK2A1 (0.38) | CSNK2A1MAPTGPR84HTR2ACYP1A2 | |
| SCHEMBL8544351 | 0.77 | HTR2A (0.45) | HTR1AHTR1BHTR1DHTR2A | |
| SCHEMBL8549767 | 0.74 | HTR2A (0.44) | HTR1AHTR1BMAPTHTR1DHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0593513-B1 | TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES | SMITHKLINE BEECHAM PLC (GB) | 1998-10-28 | — | — | EP | disclosed |
| US-5571833-A | TREATMENT OF MIGRAINE, PORTAL HYPERTENSION | SMITHKLINE BEECHAM PLC (GB) | 1996-11-05 | — | — | US | disclosed |
| EP-0593513-A1 | TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES | SMITHKLINE BEECHAM PLC (GB) | 1994-04-27 | — | — | EP | disclosed |
| WO-1993000333-A1 | TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-01-07 | — | — | WO | disclosed |