SCHEMBL8548477

SCHEMBL8548477

COc1ccc2[nH]cc(CC#N)c2c1Cl

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 2/20 0.42
CSNK2A1 P68400 3/20 0.41
HTR2A P28223 1/20 0.40
IDO1 P14902 1/20 0.39
HTR6 P50406 1/20 0.38
MTNR1A P48039 3/20 0.36
MTNR1B P49286 3/20 0.36
NQO2 P16083 1/20 0.36
CACNA1G O43497 1/20 0.35
CACNA1B Q00975 1/20 0.35
GPR84 Q9NQS5 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5680499 0.84 HTR1A (0.43) HTR1ACSNK2A1HTR2AIDO1HTR6
SCHEMBL8544872 0.84 CSNK2A1 (0.38) HTR1ACSNK2A1HTR2AGPR84
SCHEMBL8549571 0.83 HTR1B (0.37) HTR1ACSNK2A1HTR2A
SCHEMBL8869470 0.81 CSNK2A1 (0.38) CSNK2A1HTR2AGPR84
Arvelexin SCHEMBL2725123 0.79 HTR2A (0.62) HTR1AHTR2AHTR6MTNR1AMTNR1B
SCHEMBL7334679 0.79 PRKAB2 (0.38) HTR1ACSNK2A1HTR2AHTR6GPR84
SCHEMBL8549558 0.79 HTR2A (0.45) CSNK2A1HTR2AHTR6
SCHEMBL2541508 0.78 HTR2A (0.65) HTR1AHTR2AHTR6
SCHEMBL8546408 0.78 HTR1A (0.52) HTR1AHTR2AIDO1HTR6MTNR1A
SCHEMBL8544722 0.77 HTR2A (0.53) HTR1AHTR2AIDO1HTR6MTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP disclosed
US-5571833-A TREATMENT OF MIGRAINE, PORTAL HYPERTENSION SMITHKLINE BEECHAM PLC (GB) 1996-11-05 US disclosed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP disclosed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO disclosed