Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874205 | 0.88 | CHRM4 (0.42) | CHRM4MEN1KMT2ADRD4FUCA1 | |
| SCHEMBL8875798 | 0.87 | CHRM4 (0.41) | CHRM4MEN1KMT2ADRD4FUCA1 | |
| SCHEMBL8873403 | 0.81 | MEN1 (0.46) | CHRM4MEN1KMT2AFUCA1ACHE | |
| SCHEMBL9142783 | 0.79 | FNTA (0.60) | TACR1MEN1KMT2AMAPTTSHR | |
| SCHEMBL5805867 | 0.78 | MEN1 (0.50) | CHRM4MEN1KMT2ADRD4FUCA1 | |
| SCHEMBL8894771 | 0.78 | FNTA (0.46) | TACR1MEN1KMT2AMAPTTSHR | |
| SCHEMBL9139914 | 0.78 | FNTA (0.52) | TACR1MEN1KMT2AMAPTTSHR | |
| SCHEMBL8788673 | 0.78 | FNTA (0.52) | TACR1MEN1KMT2AMAPTTSHR | |
| SCHEMBL8545144 | 0.78 | TACR1 (0.48) | TACR1MEN1KMT2A | |
| SCHEMBL8893688 | 0.78 | SIGMAR1 (0.43) | TACR1CHRM4KMT2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635002-B1 | NOVEL PERHYDROISOINDOLE DERIVATIVES AND PREPARATION THEREOF | RHONE POULENC RORER SA (FR) | 1998-07-22 | — | — | EP | claimed |
| US-5463077-A | Exhibit substance P antagonist activity | RHONE-POULENC RORER S.A. (FR) | 1995-10-31 | — | — | US | claimed |
| US-5631279-A | ANTAGONISTS OF NEUROKININ A | RHONE-POULENC RORER, S.A. (FR) | 1997-05-20 | — | — | US | disclosed |
| US-5484804-A | Perhydroisoindole derivatives as antagonists of substance P | RHONE-POULENC RORER S.A. (FR) | 1996-01-16 | — | — | US | disclosed |
| US-5463077-A | Exhibit substance P antagonist activity | RHONE-POULENC RORER S.A. (FR) | 1995-10-31 | — | — | US | disclosed |