Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624797 | 0.93 | ADRB2 (0.56) | ADRB2AKT1TSHRMAPK1HIF1A | |
| SCHEMBL10989849 | 0.90 | ADRB2 (0.54) | ADRB2AKT1TSHRMAPK1HIF1A | |
| SCHEMBL9510147 | 0.87 | PTGS2 (0.39) | AKT1TP53SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12591826 | 0.82 | ADRB2 (0.56) | ADRB2AKT1TSHRMAPK1HIF1A | |
| SCHEMBL11207670 | 0.80 | TSHR (0.48) | ADRB2AKT1TSHRMAPK1HIF1A | |
| SCHEMBL1415320 | 0.79 | ESR1 (0.38) | ADRB2TDP1LMNACYP1A2SLC6A2 | |
| SCHEMBL6479076 | 0.78 | PTGS2 (0.54) | MAPK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11621775 | 0.78 | ADRB2 (0.52) | ADRB2AKT1TSHRMAPK1HIF1A | |
| SCHEMBL8008483 | 0.77 | MAPK1 (0.53) | TSHRMAPK1TDP1LMNAHPGD | |
| SCHEMBL5695686 | 0.76 | TYR (0.46) | ADRB2MAPK1HIF1ALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837848-A1 | 4-ARYL-1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES HAVING NEUROTROPHIC AND NEUROPROTECTIVE ACTIVITY | SANOFI (FR) | 1998-04-29 | — | — | EP | disclosed |
| WO-1997001536-A1 | 4-ARYL-1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES HAVING NEUROTROPHIC AND NEUROPROTECTIVE ACTIVITY | SANOFI (FR) | 1997-01-16 | — | — | WO | disclosed |