Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3599330 | 0.84 | KDM4E (0.58) | HSD17B10KDM4EPKMALDH1A1MAPT | |
| SCHEMBL7813490 | 0.83 | HSD17B10 (1.00) | HSD17B10KDM4EALDH1A1MAPTHTT | |
| SCHEMBL27484085 | 0.81 | HSD17B10 (0.56) | HSD17B10KDM4EPKMALDH1A1MAPT | |
| SCHEMBL10355393 | 0.81 | HSD17B10 (0.71) | HSD17B10KDM4EPKMALDH1A1MAPT | |
| SCHEMBL30745046 | 0.81 | HSD17B10 (0.71) | HSD17B10KDM4EPKMALDH1A1MAPT | |
| SCHEMBL1188761 | 0.81 | HSD17B10 (0.71) | HSD17B10KDM4EPKMALDH1A1MAPT | |
| SCHEMBL10920134 | 0.81 | KDM4E (0.55) | HSD17B10KDM4EPKMALDH1A1MAPT | |
| SCHEMBL19897381 | 0.80 | HSD17B10 (0.69) | HSD17B10KDM4EPKMALDH1A1MAPT | |
| SCHEMBL31096300 | 0.80 | HSD17B10 (0.69) | HSD17B10KDM4EALDH1A1MAPTGAA | |
| SCHEMBL9191019 | 0.79 | KDM4E (0.53) | HSD17B10KDM4EPKMALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755944-B1 | BIARYLDERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI SA (FR) | 2017-06-14 | — | — | EP | disclosed |
| EP-2755944-B1 | BIARYLDERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI SA (FR) | 2017-06-14 | — | — | EP | disclosed |
| US-9624159-B2 | Aniline derivatives, their preparation and their therapeutic application | SANOFI (FR) | 2017-04-18 | — | — | US | disclosed |
| US-9624159-B2 | Aniline derivatives, their preparation and their therapeutic application | SANOFI (FR) | 2017-04-18 | — | — | US | disclosed |
| US-9624159-B2 | Aniline derivatives, their preparation and their therapeutic application | SANOFI (FR) | 2017-04-18 | — | — | US | disclosed |
| US-20160199330-A1 | ANILINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2016-07-14 | — | — | US | disclosed |
| US-20160199330-A1 | ANILINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2016-07-14 | — | — | US | disclosed |
| US-20160199330-A1 | ANILINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2016-07-14 | — | — | US | disclosed |
| US-9249085-B2 | Aniline derivatives, their preparation and their therapeutic application | FOVEA PHARMACEUTICALS (FR) | 2016-02-02 | — | — | US | disclosed |
| US-9249085-B2 | Aniline derivatives, their preparation and their therapeutic application | FOVEA PHARMACEUTICALS (FR) | 2016-02-02 | — | — | US | disclosed |
| US-20140350019-A1 | ANILINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | FOVEA PHARMACEUTICALS (FR) | 2014-11-27 | — | — | US | disclosed |
| EP-2755944-A2 | ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | Fovea Pharmaceuticals (FR) | 2014-07-23 | — | — | EP | disclosed |
| WO-2013037705-A9 | ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | FOVEA PHARMACEUTICALS (FR) | 2013-09-06 | — | — | WO | disclosed |
| WO-2013037705-A9 | ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | FOVEA PHARMACEUTICALS (FR) | 2013-09-06 | — | — | WO | disclosed |
| WO-2013037705-A2 | ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | FOVEA PHARMACEUTICALS (FR) | 2013-03-21 | — | — | WO | disclosed |
| WO-2013037705-A2 | ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | FOVEA PHARMACEUTICALS (FR) | 2013-03-21 | — | — | WO | disclosed |
| EP-0654023-B1 | 5-(2-OXYPHENYL)-PYRROLE DERIVATIVES AS DOPAMINE D3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-09-16 | — | — | EP | disclosed |
| US-5523299-A | ADMINISTERING IN TREATMENT OF PSYCHOTIC DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-04 | — | — | US | disclosed |
| EP-0654023-A1 | 5-(2-OXYPHENYL)-PYRROLE DERIVATIVES AS DOPAMINE D3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003426-A1 | 5-(2-OXYPHENYL)-PYRROLE DERIVATIVES AS DOPAMINE D3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140350019-A1 | ANILINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | CYP11B1, CYP11B2, ARG2 | HSD17B10 456/4885KDM4E 3932/4885PKM 2430/4885 |
| US-20160199330-A1 | ANILINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | CYP11B1, ARG2, CYP11B2 | HSD17B10 471/4885KDM4E 3938/4885PKM 2420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.