Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.49 |
| ▸ | CMA1 | P23946 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.38 |
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31414332 | 1.00 | AHR (0.49) | AHRCMA1P2RX7PGRDRD2 | |
| SCHEMBL19235317 | 0.81 | DRD2 (0.48) | AHRCMA1P2RX7PGRDRD2 | |
| SCHEMBL2076100 | 0.81 | AHR (0.43) | AHRCMA1PGRDRD2DRD4 | |
| SCHEMBL19235316 | 0.78 | AHR (0.41) | AHRCMA1PGRDRD2DRD4 | |
| SCHEMBL9835830 | 0.78 | AHR (0.44) | AHRCMA1P2RX7PGRDRD2 | |
| SCHEMBL23252642 | 0.78 | AHR (0.41) | AHRCMA1PGRDRD2DRD4 | |
| SCHEMBL3136744 | 0.78 | AHR (0.41) | AHRCMA1PGRDRD2DRD4 | |
| SCHEMBL18289479 | 0.77 | AHR (0.50) | AHRCMA1DRD2DRD4DRD3 | |
| SCHEMBL253953 | 0.77 | AHR (0.52) | AHRCMA1PGRTDP2CCNB2 | |
| SCHEMBL27773795 | 0.75 | TDP2 (0.40) | AHRCMA1PGRDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414247-B1 | SPIROINDOLINONES AS DDR1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-04-21 | — | — | EP | disclosed |
| US-20190071444-A1 | SPIROINDOLINONES AS DDR1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2019-03-07 | — | — | US | disclosed |
| WO-2017137334-A1 | SPIROINDOLINONES AS DDR1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-08-17 | — | — | WO | disclosed |
| EP-0680321-B1 | LYSINE SALT OF 6-CHLORO-5-FLUORO-3-(2-THENOYL)-2-OXINDOLE-1-CARBOXAMIDE | PFIZER (US) | 1998-09-23 | — | — | EP | disclosed |
| EP-0399748-B1 | Process for making 2-oxindole-1-carboxamides | PFIZER (US) | 1996-01-24 | — | — | EP | disclosed |
| EP-0680321-A1 | LYSINE SALT OF 6-CHLORO-5-FLUORO-3-(2-THENOYL)-2-OXINDOLE-1-CARBOXAMIDE | PFIZER INC. (US) | 1995-11-08 | — | — | EP | disclosed |
| WO-1994016694-A1 | LYSINE SALT OF 6-CHLORO-5-FLUORO-3-(2-THENOYL)-2-OXINDOLE-1-CARBOXAMIDE | PFIZER INC. (US) | 1994-08-04 | — | — | WO | disclosed |
| EP-0608058-A1 | 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent | PFIZER INC. (US) | 1994-07-27 | — | — | EP | disclosed |
| US-5298522-A | 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio | PFIZER INC. (US) | 1994-03-29 | — | — | US | disclosed |
| US-5086186-A | Analgesic and antiinflammatory agents | PFIZER INC. (US) | 1992-02-04 | — | — | US | disclosed |
| US-4725616-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-02-16 | — | — | US | disclosed |
| US-4721712-A | 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1988-01-26 | — | — | US | disclosed |
| US-4690943-A | ENZYME INHIBITOR OF CYCLOOXYGENASE AND LIPOXYGENASE | PFIZER INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4658037-A | RHEUMATIC DISEASES | PFIZER INC. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0208510-A2 | 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents | PFIZER INC. (US) | 1987-01-14 | — | — | EP | disclosed |
| EP-0175551-A1 | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1986-03-26 | — | — | EP | disclosed |
| US-4569942-A | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1986-02-11 | — | — | US | disclosed |
| EP-0164860-A1 | N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1985-12-18 | — | — | EP | disclosed |
| US-4556672-A | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0156603-A2 | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-10-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190071444-A1 | SPIROINDOLINONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | AHR 4003/4885CMA1 3216/4885P2RX7 2384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.