Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | RXRA | P19793 | 13/20 | 0.55 |
| ▸ | RXRB | P28702 | 13/20 | 0.55 |
| ▸ | RXRG | P48443 | 10/20 | 0.55 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6307366 | 0.91 | PTGS1 (0.55) | PTGS2PTGS1EPHX2RXRARXRB | |
| SCHEMBL8547260 | 0.89 | PTGS1 (0.70) | PTGS2PTGS1EPHX2RXRARXRB | |
| SCHEMBL7505452 | 0.86 | RXRA (0.61) | PTGS2PTGS1EPHX2RXRARXRB | |
| SCHEMBL7504563 | 0.86 | RXRA (0.61) | PTGS2PTGS1EPHX2RXRARXRB | |
| SCHEMBL8545498 | 0.86 | PTGS1 (0.56) | PTGS2PTGS1EPHX2RXRARXRB | |
| SCHEMBL8552200 | 0.85 | PTGS1 (0.57) | PTGS2PTGS1EPHX2RXRARXRB | |
| SCHEMBL7502113 | 0.85 | PTGS2 (0.56) | PTGS2PTGS1EPHX2RXRARXRB | |
| SCHEMBL6307370 | 0.81 | PTGS1 (0.54) | PTGS2PTGS1EPHX2RXRARXRB | |
| SCHEMBL7501971 | 0.80 | NR4A2 (0.64) | PTGS2PTGS1EPHX2RXRARXRB | |
| SCHEMBL7510698 | 0.80 | NR4A2 (0.64) | PTGS2PTGS1EPHX2RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | claimed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | claimed |
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |