Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | RXRA | P19793 | 15/20 | 0.56 |
| ▸ | RXRB | P28702 | 15/20 | 0.56 |
| ▸ | RXRG | P48443 | 10/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545495 | 0.85 | PTGS2 (0.56) | PTGS1EPHX2PTGS2RXRARXRB | |
| SCHEMBL8552205 | 0.85 | PTGS1 (0.56) | PTGS1EPHX2PTGS2RXRARXRB | |
| SCHEMBL6307366 | 0.85 | PTGS1 (0.55) | PTGS1EPHX2PTGS2RXRARXRB | |
| SCHEMBL8545498 | 0.79 | PTGS1 (0.56) | PTGS1EPHX2PTGS2RXRARXRB | |
| SCHEMBL6307370 | 0.78 | PTGS1 (0.54) | PTGS1EPHX2PTGS2RXRARXRB | |
| SCHEMBL6314158 | 0.77 | PTGS1 (0.91) | PTGS1EPHX2PTGS2RXRARXRB | |
| SCHEMBL8547260 | 0.74 | PTGS1 (0.70) | PTGS1EPHX2PTGS2RXRARXRB | |
| SCHEMBL21805996 | 0.73 | PTGS1 (1.00) | PTGS1EPHX2PTGS2RXRARXRB | |
| SCHEMBL9452907 | 0.72 | RXRA (0.73) | PTGS1EPHX2PTGS2RXRARXRB | |
| SCHEMBL25942924 | 0.72 | RXRA (0.73) | PTGS1EPHX2PTGS2RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |