SCHEMBL8545704

SCHEMBL8545704

CCN1C=CC=CCC1=O

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DHFR P00374 1/20 0.33
ALDH1A1 P00352 2/20 0.33
MAPT P10636 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33
PKM P14618 1/20 0.33
MAPK1 P28482 1/20 0.33
RAB9A P51151 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
GMNN O75496 1/20 0.31
LMNA P02545 1/20 0.31
THPO P40225 1/20 0.31
BLM P54132 1/20 0.31
PMP22 Q01453 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
MGLL Q99685 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12649352 0.86
SCHEMBL27287079 0.75 TSHR (0.36) ALDH1A1MAPTKDM4EMEN1PKM
SCHEMBL28480300 0.75 ALDH1A1 (0.41) ALDH1A1RAB9AKMT2ASMN1; SMN2LMNA
SCHEMBL4479063 0.75 HEXA (0.34)
SCHEMBL27287081 0.72 ALDH1A1 (0.43) ALDH1A1MAPTKDM4EMEN1PKM
SCHEMBL29157597 0.72 HPGD (0.45) ALDH1A1MEN1KMT2AL3MBTL1MGLL
SCHEMBL3369576 0.71
SCHEMBL28185880 0.71
SCHEMBL4121489 0.70
SCHEMBL7946913 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0654023-B1 5-(2-OXYPHENYL)-PYRROLE DERIVATIVES AS DOPAMINE D3 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1998-09-16 EP disclosed
US-5523299-A ADMINISTERING IN TREATMENT OF PSYCHOTIC DISORDERS SMITHKLINE BEECHAM PLC (GB) 1996-06-04 US disclosed
WO-1994003426-A1 5-(2-OXYPHENYL)-PYRROLE DERIVATIVES AS DOPAMINE D3 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1994-02-17 WO disclosed
EP-0325613-A1 PENETRATION ENHANCERS FOR TRANSDERMAL DELIVERY OF SYSTEMIC AGENTS. NELSON RES & DEV (US) 1989-08-02 EP disclosed
EP-0325613-A4 PENETRATION ENHANCERS FOR TRANSDERMAL DELIVERY OF SYSTEMIC AGENTS. NELSON RES & DEV COMPANY (US) 1989-06-13 EP disclosed
WO-1988002765-A1 PENETRATION ENHANCERS FOR TRANSDERMAL DELIVERY OF SYSTEMIC AGENTS NELSON RESEARCH AND DEVELOPMENT COMPANY (US) 1988-04-21 WO disclosed