Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 2/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 7/20 | 0.42 |
| ▸ | DRD2 | P14416 | 6/20 | 0.42 |
| ▸ | HTR2A | P28223 | 5/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.42 |
| ▸ | HRH1 | P35367 | 5/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | MLNR | O43193 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545734 | 0.78 | CYP2C9 (0.47) | DRD2SLC6A3CYP2C9SIGMAR1HTR1A | |
| SCHEMBL8543289 | 0.76 | NPC1 (0.45) | RAB9AMAPT | |
| SCHEMBL8545991 | 0.76 | LMNA (0.50) | DRD3DRD2MEN1KMT2ALMNA | |
| SCHEMBL8544059 | 0.74 | MAPT (0.44) | CYP1A2MEN1KMT2AUSP2LMNA | |
| SCHEMBL8548519 | 0.73 | MAPT (0.47) | MEN1KMT2AUSP2TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL8550810 | 0.72 | MAPT (0.46) | MEN1KMT2AUSP2TSHRMAPK1 | |
| SCHEMBL8548303 | 0.71 | RAB9A (0.45) | HTR2ACYP1A2MEN1KMT2AUSP2 | |
| SCHEMBL8549930 | 0.71 | MCL1 (0.46) | CYP1A2MEN1KMT2ACYP2C9USP2 | |
| SCHEMBL8545797 | 0.70 | SLC6A9 (0.42) | SCN5ASLC6A9DRD3DRD2HTR2A | |
| SCHEMBL8545733 | 0.70 | CYP2D6 (0.47) | OPRK1OPRD1CYP2D6LMNAOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700913-B1 | 5,6-dihydro-4H-imidazo(4,5,1-ij)quinolines, processes for their preparation, their use as medicaments, and intermediate compounds | HOECHST MARION ROUSSEL INC (US) | 1998-06-03 | — | — | EP | claimed |
| US-5500423-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-03-19 | — | — | US | claimed |
| EP-0700913-B1 | 5,6-dihydro-4H-imidazo(4,5,1-ij)quinolines, processes for their preparation, their use as medicaments, and intermediate compounds | HOECHST MARION ROUSSEL INC (US) | 1998-06-03 | — | — | EP | disclosed |
| US-5563272-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-10-08 | — | — | US | disclosed |
| US-5500423-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-03-19 | — | — | US | disclosed |
| EP-0700913-A1 | 5,6-dihydro-4H-imidazo(4,5,1-ij)quinolines, processes for their preparation, their use as medicaments, and intermediate compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1996-03-13 | — | — | EP | disclosed |