Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.53 |
| ▸ | RXRB | P28702 | 8/20 | 0.53 |
| ▸ | RXRG | P48443 | 8/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553019 | 0.90 | RXRA (0.46) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8548344 | 0.87 | NR4A2 (0.51) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8546263 | 0.86 | RXRA (0.50) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8546163 | 0.83 | RXRA (0.76) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8551262 | 0.81 | MAOA (0.53) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8547846 | 0.81 | PTGS1 (0.77) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL5731953 | 0.81 | RXRA (0.59) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8548227 | 0.80 | PTGS1 (0.72) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8548370 | 0.78 | RXRA (0.60) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL7499991 | 0.78 | RXRA (0.55) | RXRARXRBRXRGPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | claimed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | claimed |
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |