Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.57 |
| ▸ | FBP1 | P09467 | 1/20 | 0.54 |
| ▸ | P4HB | P07237 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 5/20 | 0.46 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546648 | 1.00 | NFE2L2 (0.57) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL31512684 | 0.81 | FBP1 (0.58) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL13990553 | 0.81 | NFE2L2 (0.62) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL366417 | 0.81 | FBP1 (0.58) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL366416 | 0.81 | FBP1 (0.58) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL28008101 | 0.81 | FBP1 (0.58) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL3998676 | 0.81 | NFE2L2 (0.61) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL1046285 | 0.81 | NFE2L2 (0.61) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL1046286 | 0.81 | NFE2L2 (0.61) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL216268 | 0.80 | NFE2L2 (0.55) | NFE2L2FBP1P4HBMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429595-B2 | Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents | AVENTIS PHARMACEUTICALS INC. (US) | 2008-09-30 | — | — | US | disclosed |
| EP-0690842-B1 | 4-ARYLISOINDOLE ANALGESICS | ORTHO PHARMA CORP (US) | 1998-12-16 | — | — | EP | disclosed |
| US-5508424-A | REDUCED SIDE EFFECTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-04-16 | — | — | US | disclosed |
| EP-0690842-A1 | 4-ARYLISOINDOLE ANALGESICS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994022823-A1 | 4-ARYLISOINDOLE ANALGESICS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-10-13 | — | — | WO | disclosed |