Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5467252 | 0.92 | HTR1A (0.52) | CRBNMAPTHTR1AHTR2AHTR7 | |
| SCHEMBL5467106 | 0.89 | MAPT (0.52) | AKR1C4AKR1C3AKR1C2AKR1C1CRBN | |
| SCHEMBL29003200 | 0.86 | AKR1C4 (0.49) | AKR1C4AKR1C3AKR1C2AKR1C1CRBN | |
| SCHEMBL6225349 | 0.86 | EPHX2 (0.57) | MAPTHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL9165353 | 0.84 | HTR1A (0.58) | CRBNHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL29003155 | 0.83 | AKR1C4 (0.51) | AKR1C4AKR1C3AKR1C2AKR1C1CRBN | |
| SCHEMBL4851475 | 0.83 | HTR1A (0.57) | CRBNHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL10836364 | 0.81 | HTR1A (0.51) | AKR1C4AKR1C3AKR1C2AKR1C1CRBN | |
| SCHEMBL10836010 | 0.81 | SMYD3 (0.49) | CRBNMAPTHTR1AHTR2AHTR7 | |
| SCHEMBL1145012 | 0.80 | ALDH1A1 (0.55) | CRBNMAPTHTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| US-5698553-A | Benzylpiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-16 | — | — | US | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |