Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 20/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9029002 | 0.93 | ALOX5 (0.70) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9227636 | 0.84 | ALOX5 (0.63) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9210920 | 0.83 | ALOX5 (0.52) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9226267 | 0.83 | ALOX5 (0.52) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9226271 | 0.83 | ALOX5 (0.52) | ALOX5PTGS1PTGS2 | |
| SCHEMBL8547366 | 0.82 | ALOX5 (0.52) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9228198 | 0.82 | ALOX5 (0.74) | ALOX5 | |
| SCHEMBL9253013 | 0.82 | ALOX5 (0.70) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9037639 | 0.82 | ALOX5 (0.74) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9035232 | 0.82 | ALOX5 (0.70) | ALOX5PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752990-B1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER (US) | 1998-08-05 | — | — | EP | disclosed |
| US-5665749-A | Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis | PFIZER INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0752990-A1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER INC. (US) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026346-A1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER INC. (US) | 1995-10-05 | — | — | WO | disclosed |