Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1325210 | 0.77 | ALDH1A1 (0.60) | KMT2AALDH1A1GLAHPGDGAA | |
| SCHEMBL5201632 | 0.76 | ALDH1A1 (0.46) | KMT2AALDH1A1HPGDRAB9APOLB | |
| SCHEMBL4299906 | 0.75 | ALDH1A1 (0.70) | KMT2AALDH1A1GLAHPGDGAA | |
| SCHEMBL15271630 | 0.75 | ALDH1A1 (0.41) | ALDH1A1HPGDGAAKDM4EACHE | |
| SCHEMBL31465209 | 0.74 | MAPT (0.56) | KMT2AALDH1A1GLAHPGDGAA | |
| SCHEMBL28424829 | 0.74 | MAPT (0.56) | KMT2AALDH1A1GLAHPGDGAA | |
| SCHEMBL6032927 | 0.72 | LMNA (0.59) | KMT2AALDH1A1GLAHPGDGAA | |
| SCHEMBL29712310 | 0.72 | ALDH1A1 (0.58) | KMT2AALDH1A1GLAHPGDGAA | |
| SCHEMBL11690096 | 0.72 | ALDH1A1 (0.58) | KMT2AALDH1A1GLAHPGDGAA | |
| SCHEMBL30853545 | 0.72 | ALDH1A1 (0.58) | KMT2AALDH1A1GLAHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0560231-B1 | Pyrazolo(3,4-a)acridine derivatives as analgesics | HOECHST MARION ROUSSEL INC (US) | 1998-06-03 | — | — | EP | disclosed |
| EP-0560231-A1 | Pyrazolo(3,4-a)acridine derivatives as analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-09-15 | — | — | EP | disclosed |